Role of Injection of Platelet Rich Plasma in Promoting Healing Of Chronic Venous Leg Ulcer versus Conventional Compression Therapy

Document Type : Research project

Authors

1 department of surgery, faculty of medicine, port-said university, port-said, Egypt

2 clinical pathology, Port Said University, Egypt

Abstract

Background: Venous leg ulcers (VLU) consider the commonest type of leg ulceration (80%), venous insufficiency is the main cause of it. Intra lesion injection of Platelet-rich plasma (PRP) is a potential factor for promoting ulcer healing by the effect of growth factors (GF). the aim was to evaluate the efficacy and safety of (PRP) injection in chronic non-healing (VLU) versus conventional compression therapy.
Methods: a randomized prospective comparative study, in 42 patients were managed by dividing into two equal groups; Group (1) managed by PRP injection inside the VLU after preparing the ulcer for healing, and relieving the causes of non-healing ulcer (infection and necrotic tissues or venous insufficiency). Group (2) managed the ulcers by conventional compression therapy. All patients were assisted for 3, 6,9 and 12 months or until wound healing. The injection was performed weekly and evaluated.
Results: The mean percentage of wound closed of PRF injection group was discovered significantly higher than conventional group. With statistically difference in rate of healing ulcer between the PRF group and control group. The mean of reduction in ulcer area in group (1) within 12 months was 1.2 + 0.5, and in group (2) was 3.9 + 1.6. the rate of improvement was 92.7% and 77.1% respectively (P value <0.05).
Conclusions: Injection of PRP inside chronic VLU showed better clinical outcomes in comparing with conventional compression therapy alone.

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Medicine Updates
Volume 11, Issue 11
October 2022
Pages 108-123

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