Protective Roles of Chitosan Nanoparticles and Ascorbic Acid Against Chromium Induced Thyroid Toxicity in Albino Rats

Document Type : Review Article

Authors

1 Histology and Genetics department. Faculty of Medicine. Port Said University.

2 Pathology department, faculty of medicine port-said University

3 Toxicology department, faculty of Medicine, Port Said University

4 Histology and Genetics Department, faculty of Medicine, Zagazig university

Abstract

Introduction: Because of the genotoxic, carcinogenic, neurotoxic, nephrotoxic, and immunotoxic properties of hexavalent chromium (Cr VI) which is a heavy metal that is used extensively in many industries, it is considered dangerous for both humans and animals and extremely toxic to all living things. Through oxidative stress, it causes thyroid gland toxicity.
Chitosan nanoparticles are naturally occurring materials with exceptional biological, physicochemical, and antimicrobial qualities. Their bioactivity is safe for humans and they are an excellent environmentally friendly material .Chitosan is a proven antioxidant agent.
Ascorbic acid, also known as vitamin C, is a necessary micronutrient that helps humans carry out critical metabolic processes. This powerful water-soluble vitamin can be found in some foods naturally as well as as a dietary supplement. Because of its antioxidant properties, it has generated a lot of discussion.
Therefore, Chitosan nanoparticles and Ascorbic acid are known to have antioxidant effects, so they are considered important substances for humans and animals.
Aim of the work: This study aims to evaluate the protective effect of chitosan nanoparticles and ascorbic acid against thyroid toxicity induced by potassium dichromate in adult male albino rats.

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Medicine Updates
Volume 23, Issue 23
October 2025
Pages 16-29

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