The Effect of Amisulpride on Hippocampal Neurogenesis in an Experimental Model of Stressed Rats

Document Type : Original Article

Author

Pharmacology , faculty of medicine , PortSaid university

Abstract

Rationale: Amisulpride (Sanofi) is atypical antipsychotic against both positive and negative symptoms of schizophrenia . Efficacy is observed against negative symptoms in a low dose range of ( 50-300 mg / day ) while in positive symptoms is observed in a high dose range ( 800-1200 mg / day ) Boyer et al ,( 1994 ). It is a selective and potent antagonist at dopamine D2 and D3 receptors. Also it appears to have a useful potential for treatment of depression Boyer et al ,(1999).

Objectives:
The current study investigated that amisulpride has antidepressant properties over a range of doses in two procedures namely the Forced Swim Test (FST) Porso et al,(1978) and immune-histopathology of Ki67. Also the effect of high versus low dose of amisulpride on hippocampal neurogenesis in male Wistar Han albino rats.

Results:
There is an increase of immobility time in seconds in CSS group compared with Control group with Mean ± SD (67.00±8.623 and 3.333±1.670 respectively) with P treatment with oral Amisulpride 5 ,10 mg/kg/day result in insignificant increase in Ki-67 immunostained cells in SVZ, with the maximum statistically increase with 20 mg/kg/day, with means (15.78,13.38 and 28.00 respectively )compared with CSS (Mean 8.000 ) with P values of 0.5108 ,0.8187and 0.0009 respectively and F (4,40)=6.628.

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